Laurence Leherte, Kim Baxter, Janice Glasgow, and Suzanne Fortier
The segmentation and interpretation of threedimensional images of proteins is considered. A topological approach is used to represent a protein structure as a spanning tree of critical points, where each critical point corresponds to a residue or the connectivity between residues. The critical points are subsequently analyzed to recognize secondary structure motifs within the protein. Results of applying the approach to ideal and experimental images of proteins at medium resolution are presented.