Semantic Integration of Software Systems in Translational Clinical Trials

Ravi Shankar, Martin O'Connor, David Parish, Amar Das

The life cycle management of complex clinical trials typically involves disparate software applications facilitating activities such as trial design specification, clinical sites management, laboratory management, participants tracking, and data analysis. The lack of common nomenclature among the different sources of the tracking information and the unreliable nature of the data generation can lead to significant challenges in the operation of the clinical trials and the analysis of the research data. To support the management of clinical trials, we have created and validated a set of ontologies that can represent the knowledge used to execute a translational clinical trial, and have implemented an ontological framework that supports semantic interoperability among software applications that capture knowledge and data in clinical trials.

Subjects: 11.2 Ontologies; 1. Applications

Submitted: Jan 18, 2008


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