Reconstruction of Metabolic Networks Using Incomplete Information

Terry Gaasterland and Evgeni Selkov

This paper describes an approach that uses methods for automated sequence analysis and multiple databases accessed through an object+attribute view of the data, together with metabolic pathways, reaction equations, and compounds parsed into a logical representation from the Enzyme and Metabolic Pathway Database as the sources of data for automatically reconstructing a weighted partial metabolic network for a prokaryotic organism. Additional information can be provided interactively by the expert user to guide reconstruction.

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