Genomic Fold Assignment and Rational Modeling of Proteins of Biological Interest

J. Michael Sauder and Roland L. Dunbrack, Jr., Fox Chase Cancer Center

The first available genome of a multicellular organism, C. elegans, was used as a test case for protein fold assignment using PSI-BLAST, followed by rational structure modeling and interpretation of experimental mutagenesis data in the context of collaboration with biologists. Similar results are demonstrated for human disease proteins with known polymorphisms.

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