Automated Selection of Rule Induction Methods Based on Recursive Iteration of Resampling Methods and Multiple Statistical Testing

Shusaku Tsumoto, Hiroshi Tanaka

Protein structure analysis from DNA sequences is an important and fast growing area in both computer science and biochemistry. Although interesting approaches have been studied, it is very dificult to capture the characteristics of protein, since even a simple protein is made of more than 100 amino acids, which makes biochemical experiments very difficult to detect functional components. For this reason, almost all the problems in this field are left unsolved, and it is very important to develop a system which assists researchers in molecular biology to remove the difficulties caused by combinatorial explosions. In this paper we report a system, called MWI (Molecular biologists’ Workbench version 1.O), which extracts knowledge from amino-acid sequences by controlling application of domain knowledge automatically. We apply this method to comparative analysis of lysozyme and LX-lactalbumin. The results show that we obtain several interesting results from amino-acid sequences, which have not been reported before.

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