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This position paper describes the Activity-Based Computing (ABC) project which has been ongoing in Denmark since 2003. Originally, the project took its outset in the design of a pervasive computing platform suited for the mobile, collaborative, and time-critical work of clinicians in a hospital setting. Out of this grew a conceptual framework, a set of six ABC principles, and a programming and runtime framework for the development of activity-based computing infrastructures and applications. Lately, these principles and technologies have been successfully moved to other application areas, and is now used to design and implement activity-based computing support for work in a biology laboratory and for global software development.